Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment
نویسندگان
چکیده
منابع مشابه
NF-κB pathways are involved in M1 polarization of RAW 264.7 macrophage by polyporus polysaccharide in the tumor microenvironment
Bladder cancer is one of the most malignant tumors closely associated with macrophages. Polyporus polysaccharide (PPS) has shown excellent efficacy in treating bladder cancer with minimal side effects. However, the molecular mechanisms underlying the effects of PPS in inhibiting bladder cancer remain unclear. In this study, we used macrophages cultured alone or with T24 human bladder cancer cel...
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There is growing interest in reducing Bacille Calmette-Guerin (BCG) side effects while keeping intact its therapeutic efficacy. In the present study, we evaluated the efficacy of Sclerotia of Polyporus umbellatus FRIES (Zhuling) and its main ingredient Polyporus Polysaccharide (PPS) to attenuate side effects of BCG therapy in vivo. The results show that bladder cancer development in model rats ...
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Macrophages and the tumor microenvironment Tumor tissue comprises a highly complex network of diverse cell types. In a simplified view, the tumor microenvironment can be subdivided into the cancer cell and the stromal cell compartments, the latter of which harbors many different cell types. A considerable number of innate immune cells reside within the tumor microenvironment, including macropha...
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ژورنال
عنوان ژورنال: BMC Complementary Medicine and Therapies
سال: 2021
ISSN: 2662-7671
DOI: 10.1186/s12906-021-03318-x